The symptomatology and cognitive patterns were similar in both groups, with greater impairment in ME/CFS. Physical problems and mood issues were the main variables correlating with cognitive performance in post-COVID-19 patients, while in ME/CFS it was anxiety symptoms and physical fatigue. Statistically significant differences were found in sustained attention and visuospatial ability, being the ME/CFS group who presented the worst performance. Sustained attention and processing speed were impaired in 83.3% and 52.4% of ME/CFS patients while in post-COVID-19 condition were impaired in 56.2% and 41.4% of patients, respectively. Resultsīoth syndromes are characterized by excessive physical fatigue, sleep problems and myalgia. Fatigue, sleep quality, anxiety and depressive symptoms, the frequency and severity of different symptoms, olfactory function and a wide range of cognitive domains were evaluated. The sample included 42 ME/CFS and 73 post-COVID-19 condition patients. As well as verify if the affectation of smell is related to cognitive deterioration in patients with post-COVID-19 condition. To describe the cognitive impairment, neuropsychiatric symptoms, and general symptomatology in both groups, to find out if it is the same pathology. Given the similarity between both conditions, could it be the same pathology with a different precipitating factor? Objective The post-COVID-19 condition patients refer physical fatigue and cognitive impairment sequelae. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is characterized by persistent physical and mental fatigue.
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